In a large bowl, combine ground beef, egg, breadcrumbs, Worcestershire sauce, salt, garlic powder, onion powder, and black pepper. Mix until just combined, being careful not to overmix to avoid tough patties.

Divide the mixture into 6 equal portions. Shape each portion into a round, flat patty about 1/2 inch thick. Press a thumbprint in the center of each patty to prevent bulging during cooking.

Preheat a grill or skillet over medium heat. Cook the patties for about 5 minutes on each side or until they reach an internal temperature of 160°F, indicating they are fully cooked.

Serve the patties hot on burger buns with your choice of toppings such as lettuce, tomato, onion, and condiments.