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Greek Pastitsio Casserole Recipe

5 from 2 votes
Angela SellariBy Angela Sellari
Angela Sellari
Angela Sellari Founder of AboutAMom

Angela is the founder of About A Mom and currently acts as a content creator and editor-in-chief for the About A Mom Team. She has been a professional blogger for over 10 years. Angela has appeared…

Expertise: Content Creation & Editing View all posts →
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I love Greek food. There was this little Greek restaurant in Florida that I used to go to all the time with my daughters. Sadly, there aren’t any Greek restaurants near my home in Georgia.

Greek Pastitsio Casserole

Oh, how I’ve missed it. Over the last few months my daughter and I have been recreating some of our Greek restaurant favorites at home. So far we’ve have made Baklava, Spanakopita, and Pumpkin Hummus. This past week I tackled a Greek dish that might be a little less known in the U.S. and made a Greek Pastitsio Casserole. My family gobbled up this hearty casserole with it’s flavorful cream sauce. It has the traditional Greek spices like cinnamon, nutmeg and allspice.

Ingredients:

  • 12 oz. penne pasta
  • 1 1/2 lb. ground sirloin
  • 1 ½ c. yellow or white onion, chopped (1 large onion)
  • 1 ¾ tsp. salt, divided
  • 1 tsp. pepper
  • 1 tsp. Italian seasoning
  • 6 garlic cloves, finely minced
  • 2 T. all-purpose flour
  • 8 oz. reduced-fat cream cheese
  • 2 c. low-fat milk
  • 1/4 tsp. nutmeg
  • 1/2 tsp. allspice
  • 1/2 tsp. cinnamon
  • 1 (14.5 oz.) can diced tomatoes, drained
  • 1 c. shredded part-skim mozzarella cheese
  • 2 T. chopped fresh flat-leaf parsley
Greek Pastitsio Casserole Recipe

Instructions:

Step 1: Coat a 9X13-inch or equivalent baking dish with cooking spray and set aside. Preheat oven to 350 degrees.

Step 2: In a large pot of lightly salted, boiling water, cook the penne pasta according to package directions.

Step 3: While the pasta is cooking, heat a large 12-inch skillet over medium heat. Add beef or turkey to the pan with the diced onions and 1 teaspoon salt and pepper. Cook, stirring to break up the meat into small pieces, until the meat is cooked through. Drain excess grease from the meat. Add the garlic and cook until fragrant, another minute or so.

Step 4: Sprinkle the flour over the meat mixture, stirring to combine, and cook for 1-2 minutes over medium heat. Add the cream cheese in pieces, scattering it over the meat. Let it melt into the meat and stir to combine.

Step 5: Whisk or stir in the milk, nutmeg, allspice, cinnamon, 3/4 teaspoon salt, Italian seasoning and tomatoes. Stir to combine and bring the mixture to a simmer. Cook 5-6 minutes until the mixture is slightly thickened and is thoroughly heated through.

Step 6: Stir in the pasta and spoon the pasta mixture into the prepared pan. Sprinkle the mozzarella cheese evenly over the pasta and bake for 15 – 20 minutes, until the cheese is starting to brown (watching carefully so it doesn’t burn).

Step 7: Remove from the oven and sprinkle with parsley. Let it stand for about 5 minutes before serving.

Greek Pastitsio Casserole

Note: You could use 1 pound of ground sirloin in the recipe. I just wanted mine extra meaty.

This recipe Greek Pastitsio Casserole is perfect to make on the weekend and have ready for a busy weeknight. You can easily make it ahead. Just assemble everything in the afternoon, and then put it in the oven to warm it through and melt the cheese at dinner time.

Greek Pastitsio Casserole Recipe

Greek Pastitsio Casserole Recipe

Angela Sellari
This recipe Greek Pastitsio Casserole is perfect to make on the weekend and have ready for a busy weeknight. You can easily make it ahead. Just assemble everything in the afternoon, and then put it in the oven to warm it through and melt the cheese at dinner time.
5 from 2 votes
Print Recipe Pin Recipe
Prep Time 20 minutes mins
Cook Time 5 minutes mins
Total Time 25 minutes mins
Course main
Cuisine European
Servings 10
Calories 326 kcal

Ingredients
  

  • 12 ounces penne pasta
  • 1 1/2 pounds ground sirloin
  • 1 1/2 cups yellow or white onion chopped (1 large onion)
  • 1 3/4 teaspoons salt divided
  • 1 teaspoon pepper
  • 1 teaspoon Italian seasoning
  • 6 garlic cloves finely minced
  • 2 tablespoons all-purpose flour
  • 8 ounces reduced-fat cream cheese
  • 2 cups low-fat milk
  • 1/4 teaspoon nutmeg
  • 1/2 teaspoon allspice
  • 1/2 teaspoon cinnamon
  • 1 14.5 ounces can diced tomatoes, drained
  • 1 cups shredded part-skim mozzarella cheese
  • 2 tablespoons chopped fresh flat-leaf parsley

Instructions
 

  • Coat a 9X13-inch or equivalent baking dish with cooking spray and set aside. Preheat oven to 350 degrees.
  • In a large pot of lightly salted, boiling water, cook the penne pasta according to package directions.
  • While the pasta is cooking, heat a large 12-inch skillet over medium heat. Add beef or turkey to the pan with the diced onions and 1 teaspoon salt and pepper. Cook, stirring to break up the meat into small pieces, until the meat is cooked through. Drain excess grease from the meat. Add the garlic and cook until fragrant, another minute or so.
  • Sprinkle the flour over the meat mixture, stirring to combine, and cook for 1-2 minutes over medium heat. Add the cream cheese in pieces, scattering it over the meat. Let it melt into the meat and stir to combine.
  • Whisk or stir in the milk, nutmeg, allspice, cinnamon, 3/4 teaspoon salt, Italian seasoning and tomatoes. Stir to combine and bring the mixture to a simmer. Cook 5-6 minutes until the mixture is slightly thickened and is thoroughly heated through.
  • Stir in the pasta and spoon the pasta mixture into the prepared pan. Sprinkle the mozzarella cheese evenly over the pasta and bake for 15 – 20 minutes, until the cheese is starting to brown (watching carefully so it doesn’t burn).
  • Remove from the oven and sprinkle with parsley. Let it stand for about 5 minutes before serving.

Nutrition

Calories: 326kcalCarbohydrates: 21gProtein: 21gFat: 17gSaturated Fat: 8gSodium: 628mgFiber: 2g
Keyword Greek Pastitsio Casserole Recipe
Tried this recipe?Let us know how it was!

About Angela SellariContent Creation & Editing

Angela is the founder of About A Mom and currently acts as a content creator and editor-in-chief for the About A Mom Team. She has been a professional blogger for over 10 years. Angela has appeared in numerous TV segments, advertising campaigns and her work has been featured by many top publications. She lives in Tampa, Florida.

Reader Interactions

Published: Feb 24, 2014 | Updated: Oct 28, 2025
5 from 2 votes (2 ratings without comment)

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Recipe Rating




  1. Robin (Masshole Mommy) says

    Posted on 2/24 at 1:54 PM

    I love things that I can make ahead like this. I am always running around after school with the kids, so I could make this while they are at school & dinner would be all ready when we got home!

    Reply
  2. Cynthia R says

    Posted on 2/24 at 2:04 PM

    This looks so delish, I’ve been looking for a new casserole recipe to try out, I think I have a winner here. Thank you!

    Reply
  3. Wendy @ ABCs and Garden Peas says

    Posted on 2/24 at 3:21 PM

    My cousin married a man who came straight from Greece, and she makes this sometimes. It’s really fabulous!

    Reply
  4. Shell Feis says

    Posted on 2/24 at 4:43 PM

    I’ve definitely never heard of that, but it looks SO good! I love everything in it, so I’m sure I would enjoy it. Adding it to my list to make!

    Reply
  5. Debbie Denny says

    Posted on 2/24 at 5:55 PM

    That looks like a great dish.

    Reply
  6. K Squared Glamour says

    Posted on 2/24 at 6:39 PM

    This looks and sounds so delicious!

    Reply
  7. Helene Cohen Bludman says

    Posted on 2/24 at 6:46 PM

    I love pastitsio and I used to make it years ago. It is always a huge hit. So delicious.

    Reply
  8. Sandra says

    Posted on 2/24 at 7:18 PM

    YUM!! Can’t wait to try it. Beautiful photo!

    Reply
  9. Debbie L. says

    Posted on 2/24 at 7:21 PM

    Pinned – this looks delicious and easy!

    Reply
  10. Karen @TheMissingNiche says

    Posted on 2/24 at 7:32 PM

    My mouth was watering reading this! I love casseroles and this looks creamy and delicious. And it has steak in it!! I love steak! Ok, it’s ground sirloin but I am substituting cube steak! Thanks for the recipe!

    Reply
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