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Greek Pastitsio Casserole Recipe

5 from 2 votes
Angela SellariBy Angela Sellari
Angela Sellari
Angela Sellari Founder of AboutAMom

Angela is the founder of About A Mom and currently acts as a content creator and editor-in-chief for the About A Mom Team. She has been a professional blogger for over 10 years. Angela has appeared…

Expertise: Content Creation & Editing View all posts →
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I love Greek food. There was this little Greek restaurant in Florida that I used to go to all the time with my daughters. Sadly, there aren’t any Greek restaurants near my home in Georgia.

Greek Pastitsio Casserole

Oh, how I’ve missed it. Over the last few months my daughter and I have been recreating some of our Greek restaurant favorites at home. So far we’ve have made Baklava, Spanakopita, and Pumpkin Hummus. This past week I tackled a Greek dish that might be a little less known in the U.S. and made a Greek Pastitsio Casserole. My family gobbled up this hearty casserole with it’s flavorful cream sauce. It has the traditional Greek spices like cinnamon, nutmeg and allspice.

Ingredients:

  • 12 oz. penne pasta
  • 1 1/2 lb. ground sirloin
  • 1 ½ c. yellow or white onion, chopped (1 large onion)
  • 1 ¾ tsp. salt, divided
  • 1 tsp. pepper
  • 1 tsp. Italian seasoning
  • 6 garlic cloves, finely minced
  • 2 T. all-purpose flour
  • 8 oz. reduced-fat cream cheese
  • 2 c. low-fat milk
  • 1/4 tsp. nutmeg
  • 1/2 tsp. allspice
  • 1/2 tsp. cinnamon
  • 1 (14.5 oz.) can diced tomatoes, drained
  • 1 c. shredded part-skim mozzarella cheese
  • 2 T. chopped fresh flat-leaf parsley
Greek Pastitsio Casserole Recipe

Instructions:

Step 1: Coat a 9X13-inch or equivalent baking dish with cooking spray and set aside. Preheat oven to 350 degrees.

Step 2: In a large pot of lightly salted, boiling water, cook the penne pasta according to package directions.

Step 3: While the pasta is cooking, heat a large 12-inch skillet over medium heat. Add beef or turkey to the pan with the diced onions and 1 teaspoon salt and pepper. Cook, stirring to break up the meat into small pieces, until the meat is cooked through. Drain excess grease from the meat. Add the garlic and cook until fragrant, another minute or so.

Step 4: Sprinkle the flour over the meat mixture, stirring to combine, and cook for 1-2 minutes over medium heat. Add the cream cheese in pieces, scattering it over the meat. Let it melt into the meat and stir to combine.

Step 5: Whisk or stir in the milk, nutmeg, allspice, cinnamon, 3/4 teaspoon salt, Italian seasoning and tomatoes. Stir to combine and bring the mixture to a simmer. Cook 5-6 minutes until the mixture is slightly thickened and is thoroughly heated through.

Step 6: Stir in the pasta and spoon the pasta mixture into the prepared pan. Sprinkle the mozzarella cheese evenly over the pasta and bake for 15 – 20 minutes, until the cheese is starting to brown (watching carefully so it doesn’t burn).

Step 7: Remove from the oven and sprinkle with parsley. Let it stand for about 5 minutes before serving.

Greek Pastitsio Casserole

Note: You could use 1 pound of ground sirloin in the recipe. I just wanted mine extra meaty.

This recipe Greek Pastitsio Casserole is perfect to make on the weekend and have ready for a busy weeknight. You can easily make it ahead. Just assemble everything in the afternoon, and then put it in the oven to warm it through and melt the cheese at dinner time.

Greek Pastitsio Casserole Recipe

Greek Pastitsio Casserole Recipe

Angela Sellari
This recipe Greek Pastitsio Casserole is perfect to make on the weekend and have ready for a busy weeknight. You can easily make it ahead. Just assemble everything in the afternoon, and then put it in the oven to warm it through and melt the cheese at dinner time.
5 from 2 votes
Print Recipe Pin Recipe
Prep Time 20 minutes mins
Cook Time 5 minutes mins
Total Time 25 minutes mins
Course main
Cuisine European
Servings 10
Calories 326 kcal

Ingredients
  

  • 12 ounces penne pasta
  • 1 1/2 pounds ground sirloin
  • 1 1/2 cups yellow or white onion chopped (1 large onion)
  • 1 3/4 teaspoons salt divided
  • 1 teaspoon pepper
  • 1 teaspoon Italian seasoning
  • 6 garlic cloves finely minced
  • 2 tablespoons all-purpose flour
  • 8 ounces reduced-fat cream cheese
  • 2 cups low-fat milk
  • 1/4 teaspoon nutmeg
  • 1/2 teaspoon allspice
  • 1/2 teaspoon cinnamon
  • 1 14.5 ounces can diced tomatoes, drained
  • 1 cups shredded part-skim mozzarella cheese
  • 2 tablespoons chopped fresh flat-leaf parsley

Instructions
 

  • Coat a 9X13-inch or equivalent baking dish with cooking spray and set aside. Preheat oven to 350 degrees.
  • In a large pot of lightly salted, boiling water, cook the penne pasta according to package directions.
  • While the pasta is cooking, heat a large 12-inch skillet over medium heat. Add beef or turkey to the pan with the diced onions and 1 teaspoon salt and pepper. Cook, stirring to break up the meat into small pieces, until the meat is cooked through. Drain excess grease from the meat. Add the garlic and cook until fragrant, another minute or so.
  • Sprinkle the flour over the meat mixture, stirring to combine, and cook for 1-2 minutes over medium heat. Add the cream cheese in pieces, scattering it over the meat. Let it melt into the meat and stir to combine.
  • Whisk or stir in the milk, nutmeg, allspice, cinnamon, 3/4 teaspoon salt, Italian seasoning and tomatoes. Stir to combine and bring the mixture to a simmer. Cook 5-6 minutes until the mixture is slightly thickened and is thoroughly heated through.
  • Stir in the pasta and spoon the pasta mixture into the prepared pan. Sprinkle the mozzarella cheese evenly over the pasta and bake for 15 – 20 minutes, until the cheese is starting to brown (watching carefully so it doesn’t burn).
  • Remove from the oven and sprinkle with parsley. Let it stand for about 5 minutes before serving.

Nutrition

Calories: 326kcalCarbohydrates: 21gProtein: 21gFat: 17gSaturated Fat: 8gSodium: 628mgFiber: 2g
Keyword Greek Pastitsio Casserole Recipe
Tried this recipe?Let us know how it was!

About Angela SellariContent Creation & Editing

Angela is the founder of About A Mom and currently acts as a content creator and editor-in-chief for the About A Mom Team. She has been a professional blogger for over 10 years. Angela has appeared in numerous TV segments, advertising campaigns and her work has been featured by many top publications. She lives in Tampa, Florida.

Reader Interactions

Published: Feb 24, 2014 | Updated: Oct 28, 2025
5 from 2 votes (2 ratings without comment)

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Recipe Rating




  1. Taralyn says

    Posted on 2/24 at 11:27 PM

    My husband loves Greek food! I will have to make this for him!

    Reply
  2. Claudia Krusch says

    Posted on 2/24 at 11:32 PM

    I’ve been so busy, I have been looking for more and more dishes to make ahead! Your recipes sounds so good! I need to try it!

    Reply
  3. Sandra (at) Coasahmom (dot) com says

    Posted on 2/24 at 11:32 PM

    This looks SUPER yummy! Thanks so much for sharing!

    Reply
  4. Colleen says

    Posted on 2/25 at 8:19 AM

    Oh this looks amazing!

    Reply
  5. alicia k (Petite Pilates Pixie) says

    Posted on 2/25 at 8:20 AM

    this looks so decadent. I like how you used reduced fat items. Makes it a little healtheir

    Reply
  6. Debi says

    Posted on 2/25 at 8:21 AM

    It sounds like a yummy dish. I will be making it soon.

    Reply
  7. Janet W. says

    Posted on 2/25 at 8:42 AM

    What a delicious recipe! I love all of the ingredients you used in this dish. My family would love to try this and possibly add it to our meal rotation!

    Reply
  8. Mama to 5 BLessings says

    Posted on 2/25 at 9:07 AM

    oh that looks tasty, I do not think I have ever had greek food other than a Gyro!

    Reply
  9. Terin Garrett says

    Posted on 2/25 at 9:15 AM

    My mom loves Greek food also – it’s her favorite! I’ll have to attempt this and invite her over for dinner!

    Reply
  10. Kelsey Apley says

    Posted on 2/25 at 9:26 AM

    This sounds so good! I haven’t heard of a casserole quite like this, I am gonna have to make this!! Man it looks and sounds amazing!!!

    Reply
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