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Greek Pastitsio Casserole Recipe

5 from 2 votes
Angela SellariBy Angela Sellari
Angela Sellari
Angela Sellari Founder of AboutAMom

Angela is the founder of About A Mom and currently acts as a content creator and editor-in-chief for the About A Mom Team. She has been a professional blogger for over 10 years. Angela has appeared…

Expertise: Content Creation & Editing View all posts →
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I love Greek food. There was this little Greek restaurant in Florida that I used to go to all the time with my daughters. Sadly, there aren’t any Greek restaurants near my home in Georgia.

Greek Pastitsio Casserole

Oh, how I’ve missed it. Over the last few months my daughter and I have been recreating some of our Greek restaurant favorites at home. So far we’ve have made Baklava, Spanakopita, and Pumpkin Hummus. This past week I tackled a Greek dish that might be a little less known in the U.S. and made a Greek Pastitsio Casserole. My family gobbled up this hearty casserole with it’s flavorful cream sauce. It has the traditional Greek spices like cinnamon, nutmeg and allspice.

Ingredients:

  • 12 oz. penne pasta
  • 1 1/2 lb. ground sirloin
  • 1 ½ c. yellow or white onion, chopped (1 large onion)
  • 1 ¾ tsp. salt, divided
  • 1 tsp. pepper
  • 1 tsp. Italian seasoning
  • 6 garlic cloves, finely minced
  • 2 T. all-purpose flour
  • 8 oz. reduced-fat cream cheese
  • 2 c. low-fat milk
  • 1/4 tsp. nutmeg
  • 1/2 tsp. allspice
  • 1/2 tsp. cinnamon
  • 1 (14.5 oz.) can diced tomatoes, drained
  • 1 c. shredded part-skim mozzarella cheese
  • 2 T. chopped fresh flat-leaf parsley
Greek Pastitsio Casserole Recipe

Instructions:

Step 1: Coat a 9X13-inch or equivalent baking dish with cooking spray and set aside. Preheat oven to 350 degrees.

Step 2: In a large pot of lightly salted, boiling water, cook the penne pasta according to package directions.

Step 3: While the pasta is cooking, heat a large 12-inch skillet over medium heat. Add beef or turkey to the pan with the diced onions and 1 teaspoon salt and pepper. Cook, stirring to break up the meat into small pieces, until the meat is cooked through. Drain excess grease from the meat. Add the garlic and cook until fragrant, another minute or so.

Step 4: Sprinkle the flour over the meat mixture, stirring to combine, and cook for 1-2 minutes over medium heat. Add the cream cheese in pieces, scattering it over the meat. Let it melt into the meat and stir to combine.

Step 5: Whisk or stir in the milk, nutmeg, allspice, cinnamon, 3/4 teaspoon salt, Italian seasoning and tomatoes. Stir to combine and bring the mixture to a simmer. Cook 5-6 minutes until the mixture is slightly thickened and is thoroughly heated through.

Step 6: Stir in the pasta and spoon the pasta mixture into the prepared pan. Sprinkle the mozzarella cheese evenly over the pasta and bake for 15 – 20 minutes, until the cheese is starting to brown (watching carefully so it doesn’t burn).

Step 7: Remove from the oven and sprinkle with parsley. Let it stand for about 5 minutes before serving.

Greek Pastitsio Casserole

Note: You could use 1 pound of ground sirloin in the recipe. I just wanted mine extra meaty.

This recipe Greek Pastitsio Casserole is perfect to make on the weekend and have ready for a busy weeknight. You can easily make it ahead. Just assemble everything in the afternoon, and then put it in the oven to warm it through and melt the cheese at dinner time.

Greek Pastitsio Casserole Recipe

Greek Pastitsio Casserole Recipe

Angela Sellari
This recipe Greek Pastitsio Casserole is perfect to make on the weekend and have ready for a busy weeknight. You can easily make it ahead. Just assemble everything in the afternoon, and then put it in the oven to warm it through and melt the cheese at dinner time.
5 from 2 votes
Print Recipe Pin Recipe
Prep Time 20 minutes mins
Cook Time 5 minutes mins
Total Time 25 minutes mins
Course main
Cuisine European
Servings 10
Calories 326 kcal

Ingredients
  

  • 12 ounces penne pasta
  • 1 1/2 pounds ground sirloin
  • 1 1/2 cups yellow or white onion chopped (1 large onion)
  • 1 3/4 teaspoons salt divided
  • 1 teaspoon pepper
  • 1 teaspoon Italian seasoning
  • 6 garlic cloves finely minced
  • 2 tablespoons all-purpose flour
  • 8 ounces reduced-fat cream cheese
  • 2 cups low-fat milk
  • 1/4 teaspoon nutmeg
  • 1/2 teaspoon allspice
  • 1/2 teaspoon cinnamon
  • 1 14.5 ounces can diced tomatoes, drained
  • 1 cups shredded part-skim mozzarella cheese
  • 2 tablespoons chopped fresh flat-leaf parsley

Instructions
 

  • Coat a 9X13-inch or equivalent baking dish with cooking spray and set aside. Preheat oven to 350 degrees.
  • In a large pot of lightly salted, boiling water, cook the penne pasta according to package directions.
  • While the pasta is cooking, heat a large 12-inch skillet over medium heat. Add beef or turkey to the pan with the diced onions and 1 teaspoon salt and pepper. Cook, stirring to break up the meat into small pieces, until the meat is cooked through. Drain excess grease from the meat. Add the garlic and cook until fragrant, another minute or so.
  • Sprinkle the flour over the meat mixture, stirring to combine, and cook for 1-2 minutes over medium heat. Add the cream cheese in pieces, scattering it over the meat. Let it melt into the meat and stir to combine.
  • Whisk or stir in the milk, nutmeg, allspice, cinnamon, 3/4 teaspoon salt, Italian seasoning and tomatoes. Stir to combine and bring the mixture to a simmer. Cook 5-6 minutes until the mixture is slightly thickened and is thoroughly heated through.
  • Stir in the pasta and spoon the pasta mixture into the prepared pan. Sprinkle the mozzarella cheese evenly over the pasta and bake for 15 – 20 minutes, until the cheese is starting to brown (watching carefully so it doesn’t burn).
  • Remove from the oven and sprinkle with parsley. Let it stand for about 5 minutes before serving.

Nutrition

Calories: 326kcalCarbohydrates: 21gProtein: 21gFat: 17gSaturated Fat: 8gSodium: 628mgFiber: 2g
Keyword Greek Pastitsio Casserole Recipe
Tried this recipe?Let us know how it was!

About Angela SellariContent Creation & Editing

Angela is the founder of About A Mom and currently acts as a content creator and editor-in-chief for the About A Mom Team. She has been a professional blogger for over 10 years. Angela has appeared in numerous TV segments, advertising campaigns and her work has been featured by many top publications. She lives in Tampa, Florida.

Reader Interactions

Published: Feb 24, 2014 | Updated: Oct 28, 2025
5 from 2 votes (2 ratings without comment)

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Recipe Rating




  1. Liz @ A Nut in a Nutshell says

    Posted on 2/25 at 10:43 AM

    This looks so hearty and comforting. I love the spices in it!

    Reply
  2. Tammy S says

    Posted on 2/25 at 11:18 AM

    This sounds like a dish my friends mother used to make. It was great! I can’t wait to try your recipe. Thanks!

    Reply
  3. Julie Wood says

    Posted on 2/25 at 12:00 PM

    I love Greek Food, and this recipe looks so delicious and I am going to make this for a Sunday dinner. I love all the ingredients!

    Reply
  4. Lisa Jones says

    Posted on 2/25 at 2:39 PM

    This Looks So delicious I Can’t Wait To Try!!!

    Reply
  5. Cara says

    Posted on 2/25 at 7:45 PM

    This look so delicious! I will have to try this recipe for sure!

    Reply
  6. Lexie Lane says

    Posted on 2/25 at 8:20 PM

    This made me so hungry. I like Greek food and didn’t know they did pastas. This is great. I’m keeping this tabbed!

    Reply
  7. Laurie - Steals and Deals for Kids says

    Posted on 2/25 at 9:25 PM

    I have never eaten any Greek food but this looks delicious! I may have to try this one!!

    Reply
  8. Marcie W. says

    Posted on 2/26 at 8:34 AM

    This is a Greek dish I have never seen before. It looks wonderful and like an easy dinner solution too!

    Reply
  9. Danielle @ We Have It All says

    Posted on 2/26 at 2:40 PM

    This looks yummy, I’ll have to give it a shot. This is something my kids would like!

    Reply
  10. Jo-Ann Brightman says

    Posted on 2/26 at 7:33 PM

    This is a great recipe and I haven’t made it before . You said it also had cinnamon and allspice but didn’t give amounts in the recipe.

    Reply
    • Laura says

      Posted on 2/26 at 8:16 PM

      Ack! Thanks so much for catching that Jo-Ann! It’s been fixed.

      Reply
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