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Greek Pastitsio Casserole Recipe

5 from 2 votes
Angela SellariBy Angela Sellari
Angela Sellari
Angela Sellari Founder of AboutAMom

Angela is the founder of About A Mom and currently acts as a content creator and editor-in-chief for the About A Mom Team. She has been a professional blogger for over 10 years. Angela has appeared…

Expertise: Content Creation & Editing View all posts →
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I love Greek food. There was this little Greek restaurant in Florida that I used to go to all the time with my daughters. Sadly, there aren’t any Greek restaurants near my home in Georgia.

Greek Pastitsio Casserole

Oh, how I’ve missed it. Over the last few months my daughter and I have been recreating some of our Greek restaurant favorites at home. So far we’ve have made Baklava, Spanakopita, and Pumpkin Hummus. This past week I tackled a Greek dish that might be a little less known in the U.S. and made a Greek Pastitsio Casserole. My family gobbled up this hearty casserole with it’s flavorful cream sauce. It has the traditional Greek spices like cinnamon, nutmeg and allspice.

Ingredients:

  • 12 oz. penne pasta
  • 1 1/2 lb. ground sirloin
  • 1 ½ c. yellow or white onion, chopped (1 large onion)
  • 1 ¾ tsp. salt, divided
  • 1 tsp. pepper
  • 1 tsp. Italian seasoning
  • 6 garlic cloves, finely minced
  • 2 T. all-purpose flour
  • 8 oz. reduced-fat cream cheese
  • 2 c. low-fat milk
  • 1/4 tsp. nutmeg
  • 1/2 tsp. allspice
  • 1/2 tsp. cinnamon
  • 1 (14.5 oz.) can diced tomatoes, drained
  • 1 c. shredded part-skim mozzarella cheese
  • 2 T. chopped fresh flat-leaf parsley
Greek Pastitsio Casserole Recipe

Instructions:

Step 1: Coat a 9X13-inch or equivalent baking dish with cooking spray and set aside. Preheat oven to 350 degrees.

Step 2: In a large pot of lightly salted, boiling water, cook the penne pasta according to package directions.

Step 3: While the pasta is cooking, heat a large 12-inch skillet over medium heat. Add beef or turkey to the pan with the diced onions and 1 teaspoon salt and pepper. Cook, stirring to break up the meat into small pieces, until the meat is cooked through. Drain excess grease from the meat. Add the garlic and cook until fragrant, another minute or so.

Step 4: Sprinkle the flour over the meat mixture, stirring to combine, and cook for 1-2 minutes over medium heat. Add the cream cheese in pieces, scattering it over the meat. Let it melt into the meat and stir to combine.

Step 5: Whisk or stir in the milk, nutmeg, allspice, cinnamon, 3/4 teaspoon salt, Italian seasoning and tomatoes. Stir to combine and bring the mixture to a simmer. Cook 5-6 minutes until the mixture is slightly thickened and is thoroughly heated through.

Step 6: Stir in the pasta and spoon the pasta mixture into the prepared pan. Sprinkle the mozzarella cheese evenly over the pasta and bake for 15 – 20 minutes, until the cheese is starting to brown (watching carefully so it doesn’t burn).

Step 7: Remove from the oven and sprinkle with parsley. Let it stand for about 5 minutes before serving.

Greek Pastitsio Casserole

Note: You could use 1 pound of ground sirloin in the recipe. I just wanted mine extra meaty.

This recipe Greek Pastitsio Casserole is perfect to make on the weekend and have ready for a busy weeknight. You can easily make it ahead. Just assemble everything in the afternoon, and then put it in the oven to warm it through and melt the cheese at dinner time.

Greek Pastitsio Casserole Recipe

Greek Pastitsio Casserole Recipe

Angela Sellari
This recipe Greek Pastitsio Casserole is perfect to make on the weekend and have ready for a busy weeknight. You can easily make it ahead. Just assemble everything in the afternoon, and then put it in the oven to warm it through and melt the cheese at dinner time.
5 from 2 votes
Print Recipe Pin Recipe
Prep Time 20 minutes mins
Cook Time 5 minutes mins
Total Time 25 minutes mins
Course main
Cuisine European
Servings 10
Calories 326 kcal

Ingredients
  

  • 12 ounces penne pasta
  • 1 1/2 pounds ground sirloin
  • 1 1/2 cups yellow or white onion chopped (1 large onion)
  • 1 3/4 teaspoons salt divided
  • 1 teaspoon pepper
  • 1 teaspoon Italian seasoning
  • 6 garlic cloves finely minced
  • 2 tablespoons all-purpose flour
  • 8 ounces reduced-fat cream cheese
  • 2 cups low-fat milk
  • 1/4 teaspoon nutmeg
  • 1/2 teaspoon allspice
  • 1/2 teaspoon cinnamon
  • 1 14.5 ounces can diced tomatoes, drained
  • 1 cups shredded part-skim mozzarella cheese
  • 2 tablespoons chopped fresh flat-leaf parsley

Instructions
 

  • Coat a 9X13-inch or equivalent baking dish with cooking spray and set aside. Preheat oven to 350 degrees.
  • In a large pot of lightly salted, boiling water, cook the penne pasta according to package directions.
  • While the pasta is cooking, heat a large 12-inch skillet over medium heat. Add beef or turkey to the pan with the diced onions and 1 teaspoon salt and pepper. Cook, stirring to break up the meat into small pieces, until the meat is cooked through. Drain excess grease from the meat. Add the garlic and cook until fragrant, another minute or so.
  • Sprinkle the flour over the meat mixture, stirring to combine, and cook for 1-2 minutes over medium heat. Add the cream cheese in pieces, scattering it over the meat. Let it melt into the meat and stir to combine.
  • Whisk or stir in the milk, nutmeg, allspice, cinnamon, 3/4 teaspoon salt, Italian seasoning and tomatoes. Stir to combine and bring the mixture to a simmer. Cook 5-6 minutes until the mixture is slightly thickened and is thoroughly heated through.
  • Stir in the pasta and spoon the pasta mixture into the prepared pan. Sprinkle the mozzarella cheese evenly over the pasta and bake for 15 – 20 minutes, until the cheese is starting to brown (watching carefully so it doesn’t burn).
  • Remove from the oven and sprinkle with parsley. Let it stand for about 5 minutes before serving.

Nutrition

Calories: 326kcalCarbohydrates: 21gProtein: 21gFat: 17gSaturated Fat: 8gSodium: 628mgFiber: 2g
Keyword Greek Pastitsio Casserole Recipe
Tried this recipe?Let us know how it was!

About Angela SellariContent Creation & Editing

Angela is the founder of About A Mom and currently acts as a content creator and editor-in-chief for the About A Mom Team. She has been a professional blogger for over 10 years. Angela has appeared in numerous TV segments, advertising campaigns and her work has been featured by many top publications. She lives in Tampa, Florida.

Reader Interactions

Published: Feb 24, 2014 | Updated: Oct 28, 2025
5 from 2 votes (2 ratings without comment)

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Recipe Rating




  1. Mary Happymommy says

    Posted on 2/27 at 7:34 AM

    I live in the south, too, and finding ethnic food is difficult. I haven’t had Greek food in many years. Baklava was always my favorite!

    Reply
  2. LyndaS says

    Posted on 2/27 at 7:45 AM

    That looks really delicious. The only Greek food, other than desserts, that I have had would be gyros.

    Reply
  3. Vanessa: thequeenofswag says

    Posted on 3/1 at 1:51 AM

    I need to get one of those casserole dishes so I can make this. Looks amazing.

    Reply
  4. HilLesha says

    Posted on 3/1 at 9:49 PM

    I ~love~ Greek food, too. There’s a really nice one where I live, but it’s a bit pricey. I’m going to keep this recipe in mind. 🙂

    Reply
  5. TerriAnn @ Cookies & Clogs says

    Posted on 3/2 at 2:22 AM

    I love Greek food too but have no idea how to cook any of it myself. The next time I see you in person, though, you’ll have to tell me how to pronounce this. I had to read the recipe title syllable by syllable but still can’t figure out how to say ‘patitsio’ 😛

    Reply
  6. Toni says

    Posted on 3/10 at 5:36 AM

    MMM that looks so good. I love Greek dishes.

    Reply
  7. Crystal @ Simply Being Mommy.com says

    Posted on 3/10 at 11:19 AM

    That looks really, really good. Thanks for sharing this recipe. I may try it this week while the kids are on spring break.

    Reply
  8. tiffany f says

    Posted on 3/19 at 6:10 AM

    This dish looks amazing! I also live in GA and have noticed a major lack of good Greek food, which I love too. I have only seen chain places and I prefer a small family run restaurant. Thanks for sharing !!

    Reply
  9. Shannon says

    Posted on 3/25 at 4:43 PM

    Thank you very much for posting this recipe. It would be easy to make vegetarian with veggie meat strips or seitan. Have a nice day <3

    Reply
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