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HomeMealtimeRecipesCasseroles

Southwestern Turkey Casserole

4.90 from 19 votes
Angela SellariBy Angela Sellari
Angela Sellari
Angela Sellari Founder of AboutAMom

Angela is the founder of About A Mom and currently acts as a content creator and editor-in-chief for the About A Mom Team. She has been a professional blogger for over 10 years. Angela has appeared…

Expertise: Content Creation & Editing View all posts →
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Pretty soon you’ll be wondering what to do with all that leftover Thanksgiving or Christmas turkey.

Southwestern Turkey Casserole in a red dish, with a golden, crispy topping.

Turkey sandwiches are always great, but they get so boring after a couple of days. Instead use some of that leftover turkey to make a delicious meal like this Southwestern Turkey Casserole. Last week Mom and I prepared our Citrus and Herb Turkey, and then used some of the leftovers for this casserole. It was delicious, and I think I might have enjoyed the casserole more than the traditional turkey dinner we ate.

This casserole can be prepared in one large 13 inch x 9 inch baking dish. We opted to make 2 smaller casseroles. One to keep and one to send over to my brother’s house. The recipe can easily be halved – the beauty of a casserole. Since this dish has crushed tortilla chips, I recommend serving the same day it is prepared so the chips keep their crunch. I love that added texture.

Southwestern Turkey Casserole in a red baking dish, topped with golden cheese and crushed tortilla chips.

Ingredients:

  • 2 large onions, chopped
  • 1 green pepper, chopped
  • 2 tablespoons butter
  • 6 cups cubed cooked turkey
  • 2 cans (10-3/4 ounces each) condensed cream of chicken soup, undiluted
  • 2 cups (16 ounces) sour cream
  • 1 package (10 ounces) frozen chopped spinach, thawed and squeezed dry
  • 2 cups (8 ounces) shredded Monterey Jack or cheese blend
  • 1 package (12-1/2 ounces) tortilla chips, crushed

Instructions:

Step 1: Prepare greased 13 inch x 9 inch baking dish. In a medium size pot, saute onions and green pepper in butter until tender. Stir in the turkey, soup, sour cream and spinach. Spoon half of the turkey mixture into the baking dish. Then a layer of cheese and tortilla chips. Repeat layers.

Step 2: Bake casserole, uncovered, at 350 degrees for 25-30 minutes or until bubbly. Let stand for 5 minutes before serving.

Enjoy! What’s your favorite turkey leftovers recipe?

Southwestern Turkey Casserole in a red dish, with a golden, crispy topping.

Southwestern Turkey Casserole

Angela Sellari
Dive into this Southwestern Turkey Casserole recipe! Layered with cheesy turkey & tortilla chips, it's the ultimate comfort for leftovers.
4.90 from 19 votes
Print Recipe Pin Recipe
Prep Time 10 minutes mins
Cook Time 30 minutes mins
Total Time 40 minutes mins
Course Main Course
Cuisine American
Servings 12 servings
Calories 302 kcal

Ingredients
  

  • 2 large onions chopped
  • 1 green pepper chopped
  • 2 tablespoons butter
  • 6 cups cubed cooked turkey
  • 2 cans 10-3/4 ounces each condensed cream of chicken soup, undiluted
  • 2 cups 16 ounces sour cream
  • 1 package 10 ounces frozen chopped spinach, thawed and squeezed dry
  • 2 cups 8 ounces shredded Monterey Jack or cheese blend
  • 1 package 12-1/2 ounces tortilla chips, crushed

Instructions
 

  • Prepare greased 13 inch x 9 inch baking dish. In a medium size pot, saute onions and green pepper in butter until tender. Stir in the turkey, soup, sour cream and spinach. Spoon half of the turkey mixture into the baking dish. Then a layer of cheese and tortilla chips. Repeat layers.
  • Bake casserole, uncovered, at 350 degrees for 25-30 minutes or until bubbly. Let stand for 5 minutes before serving.

Nutrition

Calories: 302kcalCarbohydrates: 8gProtein: 32gFat: 16gSaturated Fat: 8gSodium: 383mgFiber: 1g
Keyword Southwestern Turkey Casserole
Tried this recipe?Let us know how it was!

About Angela SellariContent Creation & Editing

Angela is the founder of About A Mom and currently acts as a content creator and editor-in-chief for the About A Mom Team. She has been a professional blogger for over 10 years. Angela has appeared in numerous TV segments, advertising campaigns and her work has been featured by many top publications. She lives in Tampa, Florida.

Reader Interactions

Published: Nov 12, 2013 | Updated: May 18, 2026
4.90 from 19 votes (5 ratings without comment)

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Recipe Rating




  1. Lolli @ Better in Bulk says

    Posted on 11/12 at 11:36 PM

    What a great recipe for after Thanksgiving! đŸ™‚

    Reply
  2. cassie says

    Posted on 11/13 at 12:17 AM

    Looks delicious, wish I had some right now!!!

    Reply
  3. cassie says

    Posted on 11/13 at 12:19 AM

    Looks delicious, wish I had some right now!!! Definitely a comfort food with the butter and cheese, but I like how it includes spinach to make you think it is a little healthy! =)

    Reply
  4. Mistee Dawn says

    Posted on 11/13 at 1:37 AM

    That looks so good. Can’t wait to try this out.

    Reply
  5. Anne - Mommy Has to Work says

    Posted on 11/13 at 5:49 AM

    A great way to use those leftovers. We usually just have sandwiches.

    Reply
  6. Janet W. says

    Posted on 11/13 at 7:21 AM

    I love making casseroles. My favorite is chicken rice casserole. I’d love to try and make this and see how it turns out!

    Reply
  7. CinnyBBS says

    Posted on 11/13 at 8:27 AM

    That looks delish! I wish I was over for dinner

    Reply
  8. Ashley S says

    Posted on 11/13 at 8:52 AM

    My family would love this! Looks delicious

    Reply
  9. Liza @ Views From the 'Ville says

    Posted on 11/13 at 9:41 AM

    5 stars
    Casseroles are the perfect fall dish and this one sounds delicious. Your photos look so good, too!

    Reply
  10. Debi says

    Posted on 11/13 at 9:55 AM

    You are right I am always wondering what to do with the left over turkey, and I get tired of turkey and rice soup. This looks yummy.

    Reply
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